通过在独特的辣根过氧化物酶-Au 纳米粒子-聚苯胺纳米线生物膜上增强的蛋白质直接电子转移，原位分子检测缺血细胞。
In situ molecular detection of ischemic cells by enhanced protein direct electron transfer on a unique horseradish peroxidase-Au nanoparticles-polyaniline nanowires biofilm.
机构信息
Center for Advanced Bionanosystems and School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore, Singapore.
出版信息
Chem Commun (Camb). 2011 Mar 7;47(9):2652-4. doi: 10.1039/c0cc04542j. Epub 2011 Jan 13.
PMID:21234479
Abstract
To overcome shortcomings of the ex situ approaches, in situ detection using H(2)O(2) molecules to diagnose ischemia through enhanced protein direct electron transfer on a unique horseradish peroxidase-Au nanoparticles-polyaniline nanowires biofilm is demonstrated and it is discovered that the extracellular H(2)O(2) molecule released per ischemic cell is 2.7-times of that of a normal cell.
摘要
为了克服原位检测方法的缺点，通过在独特的辣根过氧化物酶-金纳米粒子-聚苯胺纳米线生物膜上增强蛋白质的直接电子转移，使用 H(2)O(2)分子原位检测缺血，结果表明，每个缺血细胞释放的细胞外 H(2)O(2)分子是正常细胞的 2.7 倍。
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