Serviço de Neurologia, Largo do Prof Abel Salazar, Centro Hospitalar do Porto/Hospital de Santo António, 4099-001 Porto, Portugal.
Neurol Sci. 2011 Oct;32(5):893-7. doi: 10.1007/s10072-010-0468-1. Epub 2011 Jan 14.
The simultaneous appearance of both multiple sclerosis (MS) and central nervous system (CNS) tumors is relatively uncommon. Whether the co-existence of two diseases is due to chance alone or the result of a causal relationship is still a matter of debate. There is also controversy about the effect of long-term exposure of MS patients to immunomodulatory drugs on the incidence of cancer. This paper reports two cases of rare CNS tumors (i.e., medulloblastoma and gliomatosis cerebri) in adult MS patients. Our cases emphasize that when uncommon neurological features appear in patients with MS, brain magnetic resonance imaging (MRI) ought to be done and brain biopsy should be considered to exclude a concomitant CNS disorder. These procedures are essential for the differential diagnosis and early treatment.
同时出现多发性硬化症（MS）和中枢神经系统（CNS）肿瘤的情况相对较少见。两种疾病的同时存在是纯属偶然，还是有因果关系，目前仍存在争议。此外，长期使用免疫调节药物治疗 MS 患者是否会增加癌症的发病率也存在争议。本文报告了两例成人 MS 患者中罕见的 CNS 肿瘤（即髓母细胞瘤和脑胶质细胞瘤）。我们的病例强调，当 MS 患者出现不常见的神经症状时，应进行脑部磁共振成像（MRI）检查，并考虑进行脑部活组织检查以排除同时存在的 CNS 疾病。这些检查对于鉴别诊断和早期治疗至关重要。
