Morita S, Tsunemoto H
Hospital Division, National Institute of Radiological Sciences NIRS.
Gan No Rinsho. 1990 Oct;36(13):2348-52.
Based on the clinical evaluations about over 1800 patients who had been treated with fast neutrons at NIRS, the radiobiological properties of high LET radiations were discussed. The most favorable clinical results by fast neutron treatment had been revealed in such diseases as follows; salivary gland tumors, prostate cancer, Pancoast type lung cancer, osteosarcoma, soft tissue sarcoma. The characteristics of these tumors as to the radiobiological properties and the dose distribution are, 1) relatively slow growing tumors and higher RBE for tumor tissue, and 2) capability of correct delivery of a big radiation doses to the target, without any severe radiation complications. Normal tissue tolerance (NSD formulas) for each tissues were also discussed.
基于对国立放射科学研究所超过1800例接受快中子治疗患者的临床评估，对高传能线密度（LET）辐射的放射生物学特性进行了讨论。快中子治疗最有利的临床结果已在以下疾病中显现：唾液腺肿瘤、前列腺癌、肺上沟瘤、骨肉瘤、软组织肉瘤。这些肿瘤在放射生物学特性和剂量分布方面的特点是：1）生长相对缓慢的肿瘤且肿瘤组织的相对生物效应（RBE）较高；2）能够将大剂量辐射准确地传递到靶区，而不会出现任何严重的放射性并发症。还讨论了各组织的正常组织耐受性（NSD公式）。
