Tsunemoto H
Division of Hospital, National Institute of Radiological Sciences.
Gan No Rinsho. 1988 Oct;34(13):1833-8.
A total number of 1623 patients were treated with fast neutrons produced by bombarding a thick Beryllium target with 30 MeV deuterons between November 1975 and December 1987. The results of clinical trials with fast neutrons have shown that carcinoma of the salivary gland and the prostate and Pancoast tumor of the lung were indications for fast neutron therapy, and that the patients suffering from osteosarcoma, malignant melanoma and soft tissue sarcoma had indications for fast neutrons when fast neutrons were combined with surgery. Neither carcinoma of the pancreas nor glioblastoma multiforme had indications because of complications of normal tissues. High LET radiation therapy will be evaluated by using heavy ions characterized by Bragg peak combined with biological effects.
1975年11月至1987年12月期间，共有1623名患者接受了用30兆电子伏特氘核轰击厚铍靶产生的快中子治疗。快中子临床试验结果表明，唾液腺癌、前列腺癌和肺上沟瘤是快中子治疗的适应症，骨肉瘤、恶性黑色素瘤和软组织肉瘤患者在快中子与手术联合使用时有快中子治疗的适应症。胰腺癌和多形性胶质母细胞瘤均因正常组织并发症而无治疗适应症。高传能线密度放射治疗将通过使用具有布拉格峰并结合生物效应的重离子进行评估。
