Morita S, Tsunemoto H, Aoki Y, Kubota S, Nakano T, Gomi H, Kumagaya K, Arai T, Sato S, Iino Y
National Institute of Radiological Sciences, Tokyo Univ.
Gan No Rinsho. 1987 Oct;33(13):1647-54.
More than 1,900 patients of advanced and inoperable malignant tumor were treated with fast neutron radiotherapy using 30 MeV (d-Be) and 14 MeV (d-Be) beams at NIRS and IMS between 1975 and 1986. Protocols were largely nonrandomized. Some results have been obtained: 1) results with mixed beam studies for advanced squamous cell carcinoma of the uterine cervix have been equivocal compared with the photon controls. 2) some trends of local control have been observed in the trial of esophageal cancer, early cases of adenocarcinoma of the lung and malignant melanoma. 3) significant better results were observed in the pancoast type lung cancer and osteo sarcoma which was treated by the systemic multimodal treatment. It is concluded that neutrons are efficacious for certain specific tumor types owing to some biological effects, however the problem of inferior dose distribution was the weakness of neutron therapy at present.
1975年至1986年间，日本国立放射医学综合研究所（NIRS）和筑波大学医学部附属医院（IMS）使用30 MeV（氘-铍）和14 MeV（氘-铍）束流对1900多名晚期和无法手术的恶性肿瘤患者进行了快中子放射治疗。治疗方案大多未随机分组。已取得了一些结果：1）与光子对照相比，晚期子宫颈鳞状细胞癌混合束研究的结果尚无定论。2）在食管癌、早期肺腺癌和恶性黑色素瘤的试验中观察到了一些局部控制趋势。3）在采用全身多模式治疗的肺上沟瘤和骨肉瘤中观察到了明显更好的结果。得出的结论是，由于某些生物学效应，中子对某些特定肿瘤类型有效，然而剂量分布较差的问题是目前中子治疗的弱点。
