Zuazu-Jausoro I, Oliver A, Monserrat I, Borrell M, Garí M, Pich I, Grau E, Fontcuberta J
Servei d'Hematologia, Hospital de la Santa Creu i Sant Pau, Barcelona.
Med Clin (Barc). 1990 Jul 7;95(6):210-3.
Anti-phosphatidylserine (APS) and anticardiolipin (ACL) antibodies were measured in 30 patients with lupus anticoagulant. In 17 cases there were clinical features of thrombosis (56.7%). The number of patients with IgG APS and ACL levels higher than seven standard deviations from the normal mean was significantly higher in the group with thrombosis (p less than 0.017 and p less than 0.02, respectively). The IgG APS level was higher in the group without systemic lupus erythematosus (p less than 0.029). There was a positive correlation between IgG APS and the activated thromboplastin time (r = 0.654, p less than 0.001). The correlation between IgG APS and IgG ACL was rho = 0.61. Two of the 5 patients with increased IgG APS and normal IgG ACL had thrombosis. We think that, in this group of patients, IgG APS titer may be, like IgG ACL, a biological marker of thrombosis risk.
对30例狼疮抗凝物患者检测了抗磷脂酰丝氨酸（APS）抗体和抗心磷脂（ACL）抗体。17例有血栓形成的临床特征（56.7%）。血栓形成组中IgG APS和ACL水平高于正常均值7个标准差的患者数量显著更多（分别为p<0.017和p<0.02）。无系统性红斑狼疮组的IgG APS水平更高（p<0.029）。IgG APS与活化部分凝血活酶时间呈正相关（r = 0.654，p<0.001）。IgG APS与IgG ACL之间的相关性为rho = 0.61。5例IgG APS升高而IgG ACL正常的患者中有2例发生了血栓形成。我们认为，在这组患者中，IgG APS滴度可能与IgG ACL一样，是血栓形成风险的生物学标志物。
