Weinstock R S, Moses A M
Veterans Administration Medical Center, Syracuse, NY.
South Med J. 1990 Dec;83(12):1475-7. doi: 10.1097/00007611-199012000-00026.
Individuals receiving lithium carbonate commonly have nephrogenic diabetes insipidus. There is no effective and practical treatment for this condition. We have found that large doses of desmopressin (DDAVP) may provide effective therapy without adverse effects. A recent report showed that indomethacin improved nephrogenic diabetes insipidus that had persisted after the lithium therapy was discontinued. We have provided additional evidence that indomethacin may be effective, even when treatment with lithium is continued. We also have shown that indomethacin together with desmopressin can markedly decrease polyuria, though indomethacin must be used with care because it may impair renal function.
接受碳酸锂治疗的个体通常会出现肾性尿崩症。这种情况没有有效的实用治疗方法。我们发现大剂量的去氨加压素（DDAVP）可能提供有效的治疗且无不良反应。最近一份报告显示，吲哚美辛改善了锂治疗停药后仍持续存在的肾性尿崩症。我们提供了更多证据表明，即使继续使用锂治疗，吲哚美辛也可能有效。我们还表明，吲哚美辛与去氨加压素一起可显著减少多尿，不过使用吲哚美辛时必须谨慎，因为它可能损害肾功能。
