Peña L, Flores J M, Castaño M, Gonzalez M
Department of Animal Pathology II, Veterinary School, Complutense University of Madrid, Spain.
Zentralbl Veterinarmed A. 1990 Sep;37(8):614-21. doi: 10.1111/j.1439-0442.1990.tb00953.x.
Experimental DMBA (7,12-dimethylbenzanthracene)-induced mammary tumours in rats were studied. Microscopic examination revealed a high rate of adenocarcinomas (95.3% in 148 mammary tumours studied). An immunohistochemical study of cytoskeleton intermediate filaments (I.F.) showed cytokeratins in neoplastic epithelial cells; myoepithelial cells expressed cytokeratins, vimentin and desmin. Finally we propose the immunocytochemical localization of desmin as a useful method to recognize myoepithelial proliferation areas in mammary tumours.
