Center for Behavioural Neuroscience, University of Düsseldorf, Germany.
Brain Res Bull. 2011 Feb 28;84(3):229-34. doi: 10.1016/j.brainresbull.2010.12.015. Epub 2011 Jan 12.
Cocaine is a major stimulant drug which can have rewarding and locomotor activating effects. It is used by non-addicts to enhance concentration and performance in a work or social setting. It was suggested that cocaine may amplify the impact of mood and sensory stimulation on behaviour. Here we tested whether cocaine can enhance the impact of novel sensory stimulation on exploratory locomotor activity. In this study the effects of cocaine (0, 2.5, 5.0, 10mg/kg, i.p.) on the locomotor response induced by on-off light stimulation with different light intensities (0, 22, 83, 440 lx) was investigated. Visual stimulation increased locomotor activity and grooming behaviour. Cocaine more dramatically increased locomotion and rearing behaviour but suppressed grooming. Also, visual stimulation effects on grooming were reduced by cocaine. The additive relationship between the cocaine and visual stimulation effects on locomotion and rearing combined with their opposing impact upon grooming point to independent mechanisms mediating cocaine- and visual stimulation-induced behavioural activation.
可卡因是一种主要的兴奋剂，具有奖赏和运动激活作用。非成瘾者使用可卡因可以在工作或社交环境中提高注意力和表现。有人认为可卡因可以放大情绪和感官刺激对行为的影响。在这里，我们测试了可卡因是否可以增强新奇感官刺激对探索性运动活动的影响。在这项研究中，我们研究了可卡因（0、2.5、5.0、10mg/kg，ip）对不同光强度（0、22、83、440 lx）开-关光刺激诱导的运动反应的影响。视觉刺激增加了运动和梳理行为。可卡因更显著地增加了运动和后肢站立行为，但抑制了梳理。此外，可卡因还减少了视觉刺激对梳理的影响。可卡因和视觉刺激对运动和后肢站立的影响具有相加关系，而对梳理的影响则相反，这表明介导可卡因和视觉刺激诱导的行为激活的机制是独立的。
