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Construction of implantable optical fibers for long-term optogenetic manipulation of neural circuits.用于长期光遗传神经回路操作的植入式光纤的构建。
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False positive in the intravenous drug self-administration test in C57BL/6J mice.C57BL/6J小鼠静脉注射药物自我给药试验中的假阳性
Behav Pharmacol. 2011 Jun;22(3):239-47. doi: 10.1097/FBP.0b013e328345f8f2.
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The effects of cocaine on light-induced activity.可卡因对光诱导活动的影响。
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Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5).操作性感觉寻求需要代谢型谷氨酸受体 5 (mGluR5)。
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Operant sensation seeking in the mouse.小鼠的操作性感觉寻求行为
J Vis Exp. 2010 Nov 10(45):2292. doi: 10.3791/2292.
6
Patterns of responding differentiate intravenous nicotine self-administration from responding for a visual stimulus in C57BL/6J mice.在 C57BL/6J 小鼠中,反应模式将静脉注射尼古丁自我给药与对视觉刺激的反应区分开来。
Psychopharmacology (Berl). 2010 Oct;212(3):283-99. doi: 10.1007/s00213-010-1950-4. Epub 2010 Jul 29.
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Amphetamine administration into the ventral striatum facilitates behavioral interaction with unconditioned visual signals in rats.安非他命给药至腹侧纹状体促进大鼠与非条件视觉信号的行为相互作用。
PLoS One. 2010 Jan 15;5(1):e8741. doi: 10.1371/journal.pone.0008741.
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Facilitation of intravenous nicotine self-administration in rats by a motivationally neutral sensory stimulus.一种动机中性的感觉刺激促进大鼠的静脉尼古丁自主给药。
Psychopharmacology (Berl). 2009 Dec;207(2):191-200. doi: 10.1007/s00213-009-1647-8. Epub 2009 Sep 16.
9
Operant sensation seeking engages similar neural substrates to operant drug seeking in C57 mice.在C57小鼠中,操作性感觉寻求与操作性药物寻求涉及相似的神经基质。
Neuropsychopharmacology. 2009 Jun;34(7):1685-94. doi: 10.1038/npp.2008.226. Epub 2009 Jan 14.
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Environmental enrichment decreases responding for visual novelty.环境丰富化会降低对视觉新奇性的反应。
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刺激动态增加了复合视觉和听觉刺激的自我给药。

Stimulus dynamics increase the self-administration of compound visual and auditory stimuli.

机构信息

Department of Molecular Physiology & Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232-0615, USA.

出版信息

Neurosci Lett. 2012 Mar 5;511(1):8-11. doi: 10.1016/j.neulet.2011.12.068. Epub 2012 Jan 9.

DOI:10.1016/j.neulet.2011.12.068
PMID:22249116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3299404/
Abstract

Animals will acquire an operant task using sensory stimuli as a primary reinforcer. Many operant tasks use sensory stimuli as cues that are paired with other primary reinforcers. Recent studies have called attention to this potential confound, but there has not been a parametric assessment of the effect of stimulus variability on operant responding. We found that stimulus variability increased the amount of operant responding exhibited by mice, a phenomenon observed under both fixed- and progressive-ratio schedules.

摘要

动物会通过感官刺激来获得操作性任务,而感官刺激本身可以作为初级强化物。许多操作性任务使用感官刺激作为线索,这些线索与其他初级强化物配对使用。最近的研究引起了人们对这种潜在混杂因素的关注,但还没有对刺激变异性对操作性反应的影响进行参数评估。我们发现,刺激变异性增加了老鼠表现出的操作性反应的数量,这种现象在固定比率和递增比率两种方案中都有观察到。