Department of Clinical and Experimental Medicine, Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy.
Thromb Res. 2011 Mar;127(3):193-7. doi: 10.1016/j.thromres.2010.12.005. Epub 2011 Jan 13.
Although patients with idiopathic VTE are at higher than normal risk of asymptomatic atherosclerosis and of cardiovascular events, the impact of cardiovascular risk factors on VTE is poorly understood.
To assess the prevalence of the metabolic syndrome and of its components in patients with early-onset idiopathic VTE.
As many as 323 patients referred to our Thrombosis Ward for a recent (<6-months) early-onset idiopathic venous thromboembolism (VTE), were compared with 868 gender- and age-matched subjects, in whom a history of venous thrombosis had been excluded, referred during the same period time to our Ward. All had undergone a clinical assessment for smoking habits and for the presence of the components of the metabolic syndrome.
The metabolic syndrome was detected in 76/323 cases (23.5%) and in 81/868 controls (9.3%) (p<0.001; OR:2.990; 95%C.I.:2.119-4.217). Smoking was more common in patients with idiopathic VTE than in controls. In addition to the metabolic syndrome as a whole, its major individual determinants (arterial hypertension, impaired fasting glucose plasma levels, abdominal obesity, hypertriglyceridemia, low HDL-cholesterol) significantly correlated with idiopathic VTE (p always <0.05). The prevalence of thrombotic events was lower in females than in males (p=0.000; OR:2.217), the latter being most often hypertensives, smokers, hypertriglyceridemics, carriers of a metabolic syndrome and of impaired fasting glucose than females. In a multivariate analysis, arterial hypertension, impaired fasting glucose, abdominal obesity, and hypercholesterolemia independently predicted idiopathic venous events.
Both metabolic syndrome as a whole and its major components individually considered, independently predict early-onset idiopathic VTE.
尽管特发性静脉血栓栓塞症（VTE）患者发生无症状动脉粥样硬化和心血管事件的风险高于正常水平，但心血管危险因素对 VTE 的影响尚不清楚。
评估早发性特发性 VTE 患者代谢综合征及其各组分的患病率。
对 323 例近期（<6 个月）早发性特发性静脉血栓栓塞症（VTE）患者进行评估，这些患者在我们的血栓病房就诊。将这些患者与同一时期在我们病房就诊且无静脉血栓病史的 868 名性别和年龄匹配的患者进行比较。所有患者均接受了吸烟习惯和代谢综合征各组分的临床评估。
323 例患者中有 76 例（23.5%）和 868 例对照者中有 81 例（9.3%）检测到代谢综合征（p<0.001；OR：2.990；95%CI：2.119-4.217）。与对照组相比，特发性 VTE 患者中吸烟更为常见。除了代谢综合征整体外，其主要的个体决定因素（高血压、空腹血糖升高、腹部肥胖、高三酰甘油血症、低高密度脂蛋白胆固醇血症）也与特发性 VTE 显著相关（p 值均<0.05）。女性的血栓事件发生率低于男性（p=0.000；OR：2.217），后者主要为高血压、吸烟者、高三酰甘油血症、携带代谢综合征和空腹血糖受损的患者。在多变量分析中，高血压、空腹血糖受损、腹部肥胖和高胆固醇血症独立预测特发性静脉事件。
代谢综合征整体及其主要成分单独考虑均可独立预测早发性特发性 VTE。
