Hemostasis Unit, Service of Clinical Pathology, La Fe University Hospital, Avenida de Campanar 21, Valencia, Spain.
Metab Syndr Relat Disord. 2011 Jun;9(3):197-201. doi: 10.1089/met.2010.0117. Epub 2011 Feb 25.
The association of metabolic syndrome with venous thromboembolism (VTE) remains uncertain. Moreover, the relevance of abdominal obesity as an independent or related risk factor for VTE in the metabolic syndrome cluster is controversial. We aimed to evaluate the impact of metabolic syndrome and its individual components on VTE risk.
We conducted a case-control study to investigate the presence of metaoblic syndrome in 150 healthy individuals (43 ± 13 years) and 146 patients with a first objectively confirmed episode of deep venous thrombosis or pulmonary embolism (44 ± 13 years) who underwent a thrombophilia work up.
Metabolic syndrome was present in 19% of cases and 8% of controls (P = 0.008). In the unadjusted analysis, metabolic syndrome was statistically associated with higher VTE risk [odds ratio (OR) = 2.7, 95% confidence interval (CI) 1.3-5.6]. However, hypertriglyceridemia (OR = 2.0, 95% CI 1.1-3.5), high glucose levels (OR = 2.0, 95% CI 1.2-3.5), and abdominal obesity (OR = 5.7, 95% CI 3.4-9.6) were also significantly associated with higher VTE risk. Abdominal obesity was the factor that had the highest OR. Moreover, after multivariate analysis in which each independent factor was adjusted for the others, only abdominal obesity remained statistically associated with higher VTE risk, revealing its relevance. Further adjustment for the presence of thrombophilia did not change the estimation.
We conclude that, in subjects with a mean age of 44 years, metabolic syndrome increases VTE risk, although abdominal obesity is the pivotal factor.
代谢综合征与静脉血栓栓塞（VTE）之间的关联尚不确定。此外，腹部肥胖作为代谢综合征簇中 VTE 的独立或相关危险因素的相关性存在争议。我们旨在评估代谢综合征及其各个成分对 VTE 风险的影响。
我们进行了一项病例对照研究，以调查 150 名健康个体（43±13 岁）和 146 名首次经客观证实的深静脉血栓形成或肺栓塞患者（44±13 岁）中代谢综合征的存在，这些患者进行了血栓形成倾向检查。
19%的病例和 8%的对照组存在代谢综合征（P=0.008）。在未调整的分析中，代谢综合征与更高的 VTE 风险具有统计学相关性[比值比（OR）=2.7，95%置信区间（CI）1.3-5.6]。然而，高甘油三酯血症（OR=2.0，95%CI 1.1-3.5）、高血糖水平（OR=2.0，95%CI 1.2-3.5）和腹部肥胖（OR=5.7，95%CI 3.4-9.6）也与更高的 VTE 风险显著相关。腹部肥胖是具有最高 OR 的因素。此外，在多元分析中，当调整其他因素时，只有腹部肥胖与更高的 VTE 风险具有统计学相关性，表明其相关性。进一步调整血栓形成倾向的存在并未改变估计值。
我们得出的结论是，在平均年龄为 44 岁的受试者中，代谢综合征会增加 VTE 风险，尽管腹部肥胖是关键因素。
