Jarrett W F, Murphy J, O'Neil B W, Laird H M
Int J Cancer. 1978 Sep 15;22(3):323-8. doi: 10.1002/ijc.2910220316.
An abattoir survey was carried out to determine the incidence and aetiology of squamous papillomas of the alimentary tract of cattle in Scotland and North England as they were suspected of being involved in the genesis of alimentary carcinoma in certain localized geographical areas. A total of 7,746 cattle of a wide age range was examined. Various subsets of this number were subjected to analyses of certain specific factors. The calculated overall incidence was 19% and the detailed site incidence and tumour multiplicity are given. The sites at which papillomas were found were identical with those at which carcinoma had been noted in animals from a high-cancer area. The number of sites affected by papilloma and the tumour multiplicity were much lower in the general population than in the high-cancer area. Inclusion bodies, identified by electronmicroscopy as virus, were found in tumour cell nuclei and a typical papilloma virus was purified from the tumours. The structure of the tumours is described and the possible plurality of bovine papilloma-viruses is discussed in the light of recent findings in the human viruses. The general interest of a naturally occurring and geographically localized oncogenic system, in which an environmental carcinogen and a virus might be involved, is extended.
开展了一项屠宰场调查，以确定苏格兰和英格兰北部牛消化道鳞状乳头瘤的发病率和病因，因为怀疑这些乳头瘤在某些局部地理区域与消化道癌的发生有关。共检查了7746头年龄范围广泛的牛。对这个数量的不同子集进行了某些特定因素的分析。计算出的总体发病率为19%，并给出了详细的部位发病率和肿瘤多发性情况。发现乳头瘤的部位与在高癌区动物中发现癌的部位相同。一般牛群中受乳头瘤影响的部位数量和肿瘤多发性远低于高癌区。通过电子显微镜鉴定为病毒的包涵体在肿瘤细胞核中被发现，并且从肿瘤中纯化出了一种典型的乳头瘤病毒。描述了肿瘤的结构，并根据人类病毒的最新发现讨论了牛乳头瘤病毒可能存在多种类型的情况。一个自然发生且在地理上局部化的致癌系统，其中可能涉及环境致癌物和病毒，其普遍意义得到了拓展。
