Campo M S, Moar M H, Sartirana M L, Kennedy I M, Jarrett W F
EMBO J. 1985 Jul;4(7):1819-25. doi: 10.1002/j.1460-2075.1985.tb03856.x.
In the Western Highlands of Scotland there is a very high incidence of alimentary cancers in cattle. The carcinomas of the upper alimentary canal are found in association with virus-induced benign papillomas, and transformation of papillomas to carcinomas has been observed. Strong circumstantial evidence suggests that the progression to malignancy is due to the interplay between the virus, bovine papillomavirus type 4 (BPV-4), and carcinogen(s) present in bracken fern, which infests the marginal upland grazing grounds. The carcinomas are often accompanied by adenomas and adenocarcinomas of the lower bowels. To elucidate the role of the virus in the transformation process, we have analysed several malignancies of the alimentary canal, and have detected the viral genome in only one case of transforming papilloma of the oesophagus and one case of carcinoma of the tongue. We conclude that, although required for the induction of papillomas, the presence of the BPV-4 DNA is not necessary for the progression to, or the maintenance of, the transformed state.
在苏格兰西部高地，牛群中消化道癌症的发病率非常高。上消化道的 carcinomas 与病毒诱导的良性乳头瘤有关，并且已经观察到乳头瘤向 carcinomas 的转变。有力的间接证据表明，恶性进展是由于病毒——牛乳头瘤病毒4型（BPV-4）与存在于蕨类植物中的致癌物之间的相互作用，蕨类植物侵扰着边缘高地牧场。 carcinomas 通常伴有下消化道的腺瘤和腺癌。为了阐明病毒在转化过程中的作用，我们分析了几例消化道恶性肿瘤，仅在1例食管转化性乳头瘤和1例舌癌中检测到病毒基因组。我们得出结论，虽然诱导乳头瘤需要BPV-4 DNA的存在，但它对于进展到转化状态或维持转化状态并非必要。
