Department of Pediatrics, Federico II University, Via S. Pansini 5, 80131 Naples, Italy.
Diabetes Res Clin Pract. 2011 Apr;92(1):53-6. doi: 10.1016/j.diabres.2010.12.028. Epub 2011 Jan 15.
To describe the prevalence of potential celiac disease (pot-CD) in young patients with type 1 diabetes mellitus (T1DM) and characterize their clinical features.
This cross-sectional multicenter study involved 8717 T1DM patients from 31 Italian centers. Information was collected on the total number of T1DM patients, CD patients and pot-CD patients. The following data were collected on pot-CD patients: gender, age at T1DM diagnosis, age at the first CD serological positivity, presence of CD-related symptoms, presence of other autoimmune disorders and treatment with gluten free diet (GFD). One thousand-three-hundred-sixty-one patients who were positive for CD serology were the control group.
CD serological positivity was found in 7.2% T1DM patients. Prevalence of pot-CD was 12.2% (n=77) among CD positive patients: symptoms were present in 12/77; a third autoimmune disorder was found in 15 patients. Prevalence of pot-CD in the control population was 8.4% (n=114; p=0.005). No difference was found with regard to clinical features. Only few symptomatic patients were on GFD both in T1DM and control patients.
A higher prevalence of pot-CD was found in T1DM patients, that may be ascribed to the routine screening, although the influence of genetic factors cannot be excluded.
描述 1 型糖尿病（T1DM）年轻患者中潜在的乳糜泻（pot-CD）的患病率，并描述其临床特征。
这是一项横断面多中心研究，纳入了来自 31 个意大利中心的 8717 名 T1DM 患者。收集了 T1DM 患者总数、CD 患者和 pot-CD 患者的信息。收集了 pot-CD 患者的以下数据：性别、T1DM 诊断时的年龄、首次 CD 血清学阳性时的年龄、是否存在 CD 相关症状、是否存在其他自身免疫性疾病以及是否接受无麸质饮食（GFD）治疗。1361 名 CD 血清学阳性的患者为对照组。
7.2%的 T1DM 患者 CD 血清学阳性。在 CD 阳性患者中，pot-CD 的患病率为 12.2%（n=77）：12/77 例有症状；15 例患者存在第三种自身免疫性疾病。对照组中 pot-CD 的患病率为 8.4%（n=114；p=0.005）。两组间临床特征无差异。仅有少数有症状的患者在 T1DM 和对照患者中接受 GFD。
T1DM 患者中发现了更高的 pot-CD 患病率，这可能归因于常规筛查，尽管不能排除遗传因素的影响。
