[Experimental study of the course of the immune response at the urinary level following repeated oral vaccination].

The Progression of the specific immunoreactions in the urines of rabbits vaccinated by oral route from 1 to 10 times with 20-40 billion of some antigens (E. coli, Proteus vulgaris, Staph aureus, Str. faecalis), administered daily or by-weekly, has been evaluated by agglutination and ELISA. The immunoenzymatic ELISA technique has revealed increases of specific immunoglobulins also one day after the first oral administration of the antigens and a final progression of IgA titres (after ten treatments) from 81% to 798%, according to the various antigens and the different posology. The highest values have been obtained using the posology of 40 billion and the bi-weekly sequence.