Iannuzzi C, Barbaro S, Viano I, Zucca M, Marazzi M G, Fonzo D, Campelli A, Lenti Bologna M, Dianzani F
G Batteriol Virol Immunol. 1979 Jan-Jun;71(1-6):100-6.
A killed E. coli 0111:K58 vaccine was administered by the oral route to 16 children ranging from 3 months to 7 years of age. The antibody response was measured at different times after the vaccination through the titration of agglutinating antibodies in serum and in fecal extracts, and the detection of specific IgA immunoglobulins in the intestinal content. All vaccines developed antibody response detectable both inserum and in fecal samples. Coproantibodies tended to appear earlier and to attain higher titers than circulating antibodies; they were all least in part IgA immunoglobulins, since the content of specific IgA in the fecal extracts was proportional to the agglutinating titer.
将一种灭活的大肠杆菌0111:K58疫苗经口服途径给予16名年龄在3个月至7岁之间的儿童。在接种疫苗后的不同时间，通过滴定血清和粪便提取物中的凝集抗体以及检测肠道内容物中的特异性IgA免疫球蛋白来测量抗体反应。所有疫苗在血清和粪便样本中均产生了可检测到的抗体反应。粪便抗体往往比循环抗体出现得更早且滴度更高；它们至少部分是IgA免疫球蛋白，因为粪便提取物中特异性IgA的含量与凝集滴度成正比。
