抗核抗体与局限性皮肤型系统性硬皮病英国队列中的临床相关性。
Antinuclear antibodies and clinical associations in a british cohort with limited cutaneous systemic sclerosis.
机构信息
Bangor University, Bangor, UK.
出版信息
J Rheumatol. 2011 Apr;38(4):702-5. doi: 10.3899/jrheum.100754. Epub 2011 Jan 15.
OBJECTIVE
To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (lcSSc).
METHODS
Sera from 180 patients with lcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies.
RESULTS
SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at lcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis.
CONCLUSION
The majority of patients with lcSSc belong to distinctive serologic subsets, potentially with prognostic significance.
目的
评估局限性皮肤系统性硬化症（lcSSc）患者的疾病特异性自身抗体的流行情况。
方法
分析了 180 例 lcSSc 患者的血清抗核抗体（ANA）。比较了存在或不存在特定自身抗体时的临床特征。
结果
135 例（75%）患者检测到 SSc 特异性抗体。抗着丝点抗体与 lcSSc 诊断时的年龄、毛细血管扩张、肌酐清除率降低和 DLCO 选择性降低以及抗拓扑异构酶-I 与肺纤维化之间存在相关性。
结论
大多数局限性皮肤系统性硬化症患者属于具有潜在预后意义的独特血清亚型。
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