Monje Argiles A, Lison D, Lauwerys R, Mahieu P, Brucher J M, Van den Bergh P
Department of Neurology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
Acta Neurol Belg. 1990;90(4):190-9.
We report a patient in whom intoxication with a commercial preparation of malathion led to a severe acute cholinergic crisis, protracted cardiac arrhythmias, an acute respiratory distress syndrome, and an acute sensorimotor axonal polyneuropathy. The occurrence of the polyneuropathy was associated with a novel malathion transformation product, S-(1-ethoxycarbonyl, 2-isopropoxycarbonyl) ethyl 0,0-dimethyl phosphorodithioate (isopropylmalathion), an impurity present in the pesticide residue. The role of isopropylmalathion in the pathophysiology of the polyneuropathy remains to be determined.
我们报告了一名患者，其因马拉硫磷商业制剂中毒导致严重急性胆碱能危象、持续性心律失常、急性呼吸窘迫综合征和急性感觉运动轴索性多神经病。多神经病的发生与一种新型马拉硫磷转化产物S-(1-乙氧羰基,2-异丙氧羰基)乙基O,O-二甲基二硫代磷酸酯（异丙基马拉硫磷）有关，该产物是农药残留中的一种杂质。异丙基马拉硫磷在多神经病病理生理学中的作用仍有待确定。
