Kolesnichenko I P
Arkh Patol. 1987;49(4):61-7.
Clinical studies of 378 patients with acute carbophose poisoning were carried out, as well as histological studies of striated muscles (gastrocnemius, anterior tibial, intercostal and phrenic) from 7 poisoned with lethal outcome due to acute oral intake of carbophose (malation). Besides, deltoid muscles (biopsy samples) of 2 severely poisoned with carbophose patients were studied histologically. Generalized paresis and paralysis of muscles of the body and the extremities, fasciculations, muscular hypotonia were found. Histologic studies revealed extensive vascular lesions, marked necrotic and necrobiotic changes in sceletal muscles and degenerative changes in the intermuscular nerve Fibers and motor endings.
对378例急性甲拌磷中毒患者进行了临床研究，并对7例因急性经口摄入甲拌磷（马拉松）致死的患者的横纹肌（腓肠肌、胫前肌、肋间肌和膈神经）进行了组织学研究。此外，还对2例甲拌磷重度中毒患者的三角肌（活检样本）进行了组织学研究。发现全身和四肢肌肉广泛性麻痹、束颤、肌张力减退。组织学研究显示广泛的血管病变、骨骼肌明显的坏死和渐进性坏死变化以及肌间神经纤维和运动终末的退行性变化。
