Elchaninov A V, Bolshakova G B
Laboratory of Growth and Development, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia.
Bull Exp Biol Med. 2011 Jan;150(3):383-6. doi: 10.1007/s10517-011-1148-8.
A reproducible model of fetal liver regeneration was created. Resection of 20% liver was carried out in rat fetuses on day 17 of prenatal development. The organ weight was restored after 2 days at the expense of an increase in hepatocyte mitotic activity; cell hypertrophy was minor. After recovery, the cell composition of the operated liver did not differ from the control, i.e. the regeneration was organotypical.
建立了一个可重复的胎儿肝脏再生模型。在产前发育第17天对大鼠胎儿进行20%肝脏切除术。2天后器官重量得以恢复，这是以肝细胞有丝分裂活性增加为代价的；细胞肥大程度较轻。恢复后，手术肝脏的细胞组成与对照组无异，即再生是器官典型性的。
