Romero-Aroca Pedro, Masip-Serra Robert, Martínez-Salcedo Inmaculada, Salvat-Serra Merce, Fernández-Ballart Joan, Bautista-Pérez Angel
Ophthalmology Service, Hospital Universitari Sant Joan, IISPV, Universidad Rovira i Virgili, Reus, Spain.
Eur J Ophthalmol. 2011 Sep-Oct;21(5):580-8. doi: 10.5301/EJO.2011.6254.
To determine the prevalence of pseudoexfoliation syndrome (PEX) in our health area, in 4 counties of Tarragona, and its involvement in the health status of the population.
This was a cross-sectional study of a sample of 2,342 inhabitants aged = 60 years, randomly selected from the population census. Subjects were classified in 3 groups according to age (group 1 = 60-69 years, group 2 = 70-79 years, group 3 = over 80 years). The diagnosis of PEX was made in all cases by the same ophthalmologist, using biomicroscopic and slit-lamp evaluation. Corneal endothelial study was made by specular microscope.
The prevalence of PEX was 309/2,342 patients (13.19%), unilateral in 219/309 (70.87%). The prevalence of PEX in patients with open-angle glaucoma was 29.48%. Changes in corneal endothelium were higher in patients with PEX, with lower cell density and hexagonality percentage, with higher coefficient of variation, significant in age groups 2 and 3. The prevalence of cataract in patients with PEX was 80.58%, versus 54.64% in patients without PEX. Complications of cataract surgery were higher in patients with PEX and postoperative corneal edema was best correlated with a low hexagonality percentage. No systemic cardiovascular diseases were significant in patients with PEX.
In our health district area, a high prevalence of PEX exists. A more extensive study of the causes of these differences is needed, including analysis of the genetic makeup of the population.
确定在塔拉戈纳省4个县的我们的健康区域内假性剥脱综合征（PEX）的患病率及其对人群健康状况的影响。
这是一项横断面研究，从人口普查中随机抽取了2342名年龄≥60岁的居民作为样本。根据年龄将受试者分为3组（第1组=60-69岁，第2组=70-79岁，第3组=80岁以上）。所有病例的PEX诊断均由同一位眼科医生通过生物显微镜和裂隙灯评估进行。通过镜面显微镜进行角膜内皮研究。
PEX的患病率为309/2342例患者（13.19%），其中219/309例（70.87%）为单侧患病。开角型青光眼患者中PEX的患病率为29.48%。PEX患者的角膜内皮变化更大，细胞密度和六边形百分比更低，变异系数更高，在第2组和第3年龄组中具有显著性。PEX患者中白内障的患病率为80.58%，而无PEX患者中为54.64%。PEX患者白内障手术的并发症更高，术后角膜水肿与低六边形百分比的相关性最好。PEX患者中无明显的全身性心血管疾病。
在我们的健康区域，PEX的患病率很高。需要对这些差异的原因进行更广泛的研究，包括对人群基因构成的分析。
