Department of Psychiatry and Neurosexology, HagaHospital, The Hague, The Netherlands.
J Sex Med. 2011 Apr;8(4):1164-70. doi: 10.1111/j.1743-6109.2010.02166.x. Epub 2011 Jan 17.
Postorgasmic illness syndrome (POIS) is a combination of local allergic symptoms and transient flu-like illness. In this study, the investigators propose five preliminary criteria to establish the diagnosis.
To describe the clinical details in 45 males being suspected of having POIS and to test an immunogenic hypothesis as the underlying mechanism of their presentations.
Forty-five males were studied according to standardized protocol, including neuropsychiatric and medical sexological evaluations; their complaints were categorized using their own words, and their self-perceived intravaginal ejaculation latency time (IELT). Skin-prick testing with autologous diluted semen in 33 men were also performed.
Clinical features of POIS including self-perceived IELTs and the results of skin-prick testing with autologous diluted seminal fluid.
Of the 45 included men, 33 subjects consented with skin-prick testing. Of them, 29 (88%) men had a positive skin-prick test with their own (autologous) semen, and four had a negative test. In 87% of men, POIS symptoms started within 30 minutes after ejaculation. Complaints of POIS were categorized in seven clusters of symptoms, e.g., general, flu-like, head, eyes, nose, throat, and muscles. Local allergic reactions of eyes and nose were reported in 44% and 33% of subjects, a flu-like syndrome in 78% of subjects, exhaustion and concentration difficulties in 80% and 87% of subjects. Of all subjects, 58% had an atopic constitution. Lifelong premature ejaculation, defined as self-perceived IELT < 1 minute, was reported in 25 (56%) of subjects.
The combination of allergic and systemic flu-like reactions post-ejaculation together with a positive skin-prick test in the majority of males underscores the hypothesis of an "immunogenic" etiology of POIS, e.g., that POIS is caused by Type-1 and Type-IV allergy to the males' own semen, as soon it is triggered by ejaculation.
射精后疾病综合征（POIS）是局部过敏症状和短暂流感样疾病的组合。在这项研究中，研究者提出了五个初步标准来确立诊断。
描述 45 名疑似患有 POIS 的男性的临床细节，并测试一种免疫原性假说作为其表现的潜在机制。
根据标准化方案对 45 名男性进行研究，包括神经精神和医学性学评估；他们的主诉用自己的话进行分类，并且他们自我感知的阴道内射精潜伏期时间（IELT）。对 33 名男性进行了自体稀释精液的皮肤点刺试验。
包括自我感知的 IELT 和自体稀释精液皮肤点刺试验结果的 POIS 临床特征。
在纳入的 45 名男性中，有 33 名男性同意进行皮肤点刺试验。其中，29 名（88%）男性对自身（自体）精液的皮肤点刺试验呈阳性，4 名呈阴性。在 87%的男性中，POIS 症状在射精后 30 分钟内开始。POIS 的症状分为七类症状，如一般、流感样、头部、眼睛、鼻子、喉咙和肌肉。44%和 33%的受试者报告出现眼部和鼻部局部过敏反应，78%的受试者出现流感样综合征，80%和 87%的受试者出现疲劳和注意力集中困难。所有受试者中，58%有特应性体质。25 名（56%）受试者报告存在终生性早泄，定义为自我感知的 IELT<1 分钟。
大多数男性在射精后出现过敏和全身流感样反应的组合，以及大多数男性的皮肤点刺试验阳性，突出了“免疫原性”POIS 病因假说，即 POIS 是由男性自身精液的 1 型和 4 型过敏引起的，一旦精液被触发，就会引发 POIS。
