Quan Yong-Xi, Lao Ye-Dong, Wu Hui-Yi, He Xing-Xiang, Wu Li-Hao
Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, China.
Sex Med. 2024 Mar 27;12(2):qfae015. doi: 10.1093/sexmed/qfae015. eCollection 2024 Apr.
Postorgasmic illness syndrome (POIS) is characterized by allergic symptoms and flu-like illness after ejaculation. There are still no effective treatments for POIS.
To report the first case of washed microbiota transplantation (WMT) to treat patient with POIS.
Data were collected from a patient with POIS who had received 3 courses of WMT: self-rating scale of POIS symptoms, Self-rating Anxiety Scale, Self-rating Depression Scale, and Symptom Checklist 90. The patient's stool samples for 16sDNA sequencing were collected 1 month after WMT.
POIS symptoms improved after WMT. Scores decreased from baseline after WMT: self-rating scale of POIS symptoms (before WMT, 16; after first, 16; after second, 8; after third, 9), Self-rating Anxiety Scale (45, 42.5, 37.5, 45), Self-rating Depression Scale (63.75, 58.75, 47.5, 50), and Symptom Checklist 90 (143, 140, 109, 149). Characteristics of the patient's gut microbiota changed. At the genus level, the relative abundance of beneficial bacteria increased, and some opportunistic pathogenic bacteria decreased.
WMT may be an effective and safe choice for the treatment of patients with POIS by changing the gut microbiota of the host.
射精后疾病综合征（POIS）的特征是射精后出现过敏症状和类似流感的疾病。目前尚无针对POIS的有效治疗方法。
报告首例采用洗肠菌群移植（WMT）治疗POIS患者的病例。
收集一名接受了3个疗程WMT的POIS患者的数据：POIS症状自评量表、焦虑自评量表、抑郁自评量表和症状自评量表90。在WMT后1个月收集患者的粪便样本进行16sDNA测序。
WMT后POIS症状有所改善。WMT后各量表评分较基线下降：POIS症状自评量表（WMT前16分；第一次后16分；第二次后8分；第三次后9分）、焦虑自评量表（45分、42.5分、37.5分、45分）、抑郁自评量表（63.75分、58.75分、47.5分、50分）和症状自评量表90（143分、140分、109分、149分）。患者肠道微生物群的特征发生了变化。在属水平上，有益菌的相对丰度增加，一些机会致病菌减少。
通过改变宿主的肠道微生物群，WMT可能是治疗POIS患者的一种有效且安全的选择。
