Post-Orgasmic Illness Syndrome (POIS) is a rare medical condition characterized by a range of distressing physical and cognitive symptoms that occur following ejaculation in affected individuals. Little is known about the complex interaction between self-esteem and relationship factors that affect those living with POIS. This study investigated the impact of POIS on intimate relationships and feelings of isolation and stigmatization, including questions related to personal and partner control over symptoms. Furthermore, it aims to provide a clinical framework for addressing the psychosocial concerns of this patient population and their partners. Eighty-three patients (76.3% white, 37.5% with Bachelor's degree, 73.8% middle income or higher) with POIS completed the Sexual Dysfunction Attribution Scale (SDAS) as part of the larger survey study. Surveys were distributed via social media, online groups, and forums including the subreddit: "POIS", Twitter, and "POISCENTER" and were completed between 05/21/24-06/09/24. Descriptive, exploratory, and demographic data of the participants are provided from this survey. Patients with POIS were likely to report feeling no personal control over their symptoms (81.9%), feeling that their symptoms would "always be present" (96.4%), and feeling that they were personally to blame for their sexual dysfunction (60.2%). Overall, 80.7% reported that their symptoms negatively affected their relationships, and 37.3% reported not having sex within the past year. Our results can help providers to understand the experiences of patients with POIS and equip them to recommend the appropriate resources. Further research may use advanced analytical and qualitative techniques to better elucidate this population's challenges.