皮质醇是否是冠状动脉旁路移植术后谵妄发病机制的关键？
Is cortisol the key to the pathogenesis of delirium after coronary artery bypass graft surgery?
机构信息
Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Czechoslowacka 8/10, 92-216 Lodz, Poland.
出版信息
Crit Care. 2011 Jan 13;15(1):102. doi: 10.1186/cc9372.
Abstract
Postoperative delirium is a serious complication of cardiac surgery. However, the pathophysiology of this mental syndrome is largely unknown. Recent findings suggest an association between elevated level of cortisol and postoperative delirium. Further studies should investigate the mechanisms responsible for excessive perioperative cortisol secretion.
摘要
术后谵妄是心脏手术的严重并发症。然而，这种精神综合征的病理生理学在很大程度上尚不清楚。最近的研究结果表明，皮质醇水平升高与术后谵妄之间存在关联。进一步的研究应探讨导致围手术期皮质醇分泌过多的机制。
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本文引用的文献
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Crit Care. 2010;14(6):R238. doi: 10.1186/cc9393. Epub 2010 Dec 30.
2
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Crit Care. 2010;14(5):R171. doi: 10.1186/cc9273. Epub 2010 Sep 27.
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