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皮质醇是否是冠状动脉旁路移植术后谵妄发病机制的关键？

Is cortisol the key to the pathogenesis of delirium after coronary artery bypass graft surgery?

机构信息

Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Czechoslowacka 8/10, 92-216 Lodz, Poland.

出版信息

Crit Care. 2011 Jan 13;15(1):102. doi: 10.1186/cc9372.

DOI:10.1186/cc9372
PMID:21241525
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3222018/
Abstract

Postoperative delirium is a serious complication of cardiac surgery. However, the pathophysiology of this mental syndrome is largely unknown. Recent findings suggest an association between elevated level of cortisol and postoperative delirium. Further studies should investigate the mechanisms responsible for excessive perioperative cortisol secretion.

摘要

术后谵妄是心脏手术的严重并发症。然而，这种精神综合征的病理生理学在很大程度上尚不清楚。最近的研究结果表明，皮质醇水平升高与术后谵妄之间存在关联。进一步的研究应探讨导致围手术期皮质醇分泌过多的机制。

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本文引用的文献

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High serum cortisol level is associated with increased risk of delirium after coronary artery bypass graft surgery: a prospective cohort study.高血清皮质醇水平与冠状动脉旁路移植术后谵妄风险增加相关：一项前瞻性队列研究。
Crit Care. 2010;14(6):R238. doi: 10.1186/cc9393. Epub 2010 Dec 30.
2
Delirium as a predictor of sepsis in post-coronary artery bypass grafting patients: a retrospective cohort study.术后冠状动脉旁路移植术后患者发生脓毒症的预测因子：一项回顾性队列研究。
Crit Care. 2010;14(5):R171. doi: 10.1186/cc9273. Epub 2010 Sep 27.
3
Early postoperative delirium after open-heart cardiac surgery is associated with decreased bispectral EEG and increased cortisol and interleukin-6.心脏直视手术后早期谵妄与脑电双频指数降低及皮质醇和白细胞介素-6升高有关。
Intensive Care Med. 2010 Dec;36(12):2081-9. doi: 10.1007/s00134-010-2004-4. Epub 2010 Aug 6.
4
Incidence and predictors of delirium after cardiac surgery: Results from The IPDACS Study.心脏手术后谵妄的发生率和预测因素：来自 IPDACS 研究的结果。
J Psychosom Res. 2010 Aug;69(2):179-85. doi: 10.1016/j.jpsychores.2010.02.009. Epub 2010 Mar 30.
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Incidence and risk factors of delirium in critically ill patients after non-cardiac surgery.非心脏手术后危重症患者发生谵妄的发生率及危险因素。
Chin Med J (Engl). 2010 Apr 20;123(8):993-9.
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The association between delirium and the apolipoprotein E epsilon 4 allele: new study results and a meta-analysis.痴呆与载脂蛋白 E ε4 等位基因的关联：新的研究结果和荟萃分析。
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The association of the dopamine transporter gene and the dopamine receptor 2 gene with delirium, a meta-analysis.多巴胺转运体基因与多巴胺受体 2 基因与谵妄的关联：一项荟萃分析。
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J Am Geriatr Soc. 2008 Dec;56(12):2278-84. doi: 10.1111/j.1532-5415.2008.02013.x.