Centers for Disease Control and Prevention, 1600 Clifton Rd. NE, MS-A47, Atlanta, GA 30333, USA.
Vaccine. 2011 Apr 12;29(17):3329-34. doi: 10.1016/j.vaccine.2010.12.122. Epub 2011 Jan 15.
We determined impact and cost-effectiveness of pneumococcal and rotavirus vaccination programs among children<5 years of age in Uganda from the public health system perspective. Disease-specific models compared the disease burden and cost with and without a vaccination program. If introduced, pneumococcal and rotavirus vaccine programs will save 10,796 and 5265 lives, respectively, prevent 94,071 Streptococcus pneumoniae and 94,729 rotavirus cases in children<5 years, and save 3886 and 996 million Ugandan shillings ($2.3 and $0.6 million US dollars), respectively, in direct medical costs annually. At the GAVI price ($0.15/dose), pneumococcal vaccine will be cost-saving and rotavirus vaccine highly cost-effective.
我们从公共卫生系统的角度出发，确定了在乌干达五岁以下儿童中进行肺炎球菌和轮状病毒疫苗接种计划的影响和成本效益。疾病特异性模型比较了有和没有疫苗接种计划时的疾病负担和成本。如果引入，肺炎球菌和轮状病毒疫苗接种计划将分别挽救 10796 和 5265 名五岁以下儿童的生命，预防 94071 例肺炎球菌和 94729 例轮状病毒病例，并分别节省 3886 和 9960 亿乌干达先令（2300 万美元和 600 万美元）的直接医疗费用。按照全球疫苗免疫联盟的价格（每剂 0.15 美元），肺炎球菌疫苗将具有成本效益，而轮状病毒疫苗则具有高度成本效益。
