自体皮肤成纤维细胞和角质形成细胞移植治疗老年2型糖尿病患者慢性足部溃疡
Autologous skin fibroblast and keratinocyte grafts in the treatment of chronic foot ulcers in aging type 2 diabetic patients.
作者信息
Monami Matteo, Vivarelli Maria, Desideri Carla Maria, Ippolito Giulio, Marchionni Niccolò, Mannucci Edoardo
机构信息
Unit of Geriatric Medicine, Department of Cardiovascular Medicine, University of Florence and Azienda Ospedaliera Careggi, Florence, Italy.
出版信息
J Am Podiatr Med Assoc. 2011 Jan-Feb;101(1):55-8. doi: 10.7547/1010055.
BACKGROUND
we assessed the tolerability and efficacy of autologous skin cell grafts in older type 2 diabetic patients with chronic foot ulcers.
METHODS
treatment with Hyalograft 3D and Laserskin Autograft was proposed to a consecutive series of type 2 diabetic patients older than 65 years affected by long-standing (>6 months) foot ulcers with an area greater than 15 cm(2). Ulcer healing rates and measurements of ulcer area were determined monthly for 12 months.
RESULTS
seven patients with 12 ulcers, nine of which received the described treatment, were enrolled. During 12-month follow-up, all of the ulcers healed except one. In the remaining eight ulcers, the median healing time was 21 weeks (interquartile range, 4-29 weeks).
CONCLUSIONS
autologous skin cell grafts are feasible, well tolerated, and apparently effective in the treatment of diabetic ulcers of the lower limbs in advanced age. Age did not seem to moderate healing times.
背景
我们评估了自体皮肤细胞移植对老年2型糖尿病慢性足部溃疡患者的耐受性和疗效。
方法
对一系列连续的65岁以上、患有长期（>6个月）足部溃疡且溃疡面积大于15平方厘米的2型糖尿病患者，采用Hyalograft 3D和Laserskin自体移植进行治疗。在12个月内每月测定溃疡愈合率和溃疡面积。
结果
纳入7例患者的12处溃疡，其中9处接受了上述治疗。在12个月的随访中，除1处溃疡外，其余均愈合。在其余8处溃疡中，愈合时间中位数为21周（四分位间距为4 - 29周）。
结论
自体皮肤细胞移植在高龄患者下肢糖尿病溃疡的治疗中可行、耐受性良好且明显有效。年龄似乎并未影响愈合时间。
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