Public Health Research Unit, Department of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
Dement Geriatr Cogn Disord. 2011;31(2):89-97. doi: 10.1159/000323317. Epub 2011 Jan 15.
BACKGROUND/AIMS: Conversion rates to dementia are known to be high for patients with mild cognitive impairment (MCI), but the diagnosis of MCI is very time-consuming. Since the Clock Drawing Test (CDT) is quick to administer, it will be of interest to compare the predictive validity of the CDT and of an MCI diagnosis for the diagnosis of dementia.
In a sample of 384 individuals, CDT scores and the presence of MCI were assessed at baseline and then compared between individuals with an incident dementia diagnosis at follow-up and those without. Multivariate analyses, receiver operating characteristic analyses and values of sensitivity and specificity of the CDT were performed.
Individuals with incident dementia had significantly higher CDT scores at baseline than those without dementia. CDT was a significant predictor of incident dementia after adjusting for other factors. CDT reached a sensitivity of 68% and specificity of 65%. The area under the receiver operating characteristic curve of CDT was 0.70 and therefore slightly lower than for MCI diagnosis (0.78).
Because of the only slightly lower predictive value of the CDT, its quick application and scoring compared to the MCI concept applied, it will be worthwhile to improve the CDT scoring system in order to increase the predictive validity in dementia.
背景/目的：轻度认知障碍（MCI）患者向痴呆转化的转化率已知很高，但 MCI 的诊断非常耗时。由于画钟测验（CDT）的实施速度很快，因此比较 CDT 和 MCI 诊断对痴呆的预测效力将是很有意义的。
在 384 名个体的样本中，在基线时评估 CDT 评分和 MCI 的存在情况，然后将随访时发生痴呆诊断的个体与未发生痴呆的个体进行比较。进行了多变量分析、受试者工作特征分析以及 CDT 的敏感性和特异性值。
患有新发痴呆症的个体在基线时的 CDT 评分明显高于没有痴呆症的个体。在调整了其他因素后，CDT 是新发痴呆症的一个显著预测因素。CDT 的灵敏度为 68%，特异性为 65%。CDT 的受试者工作特征曲线下面积为 0.70，因此略低于 MCI 诊断（0.78）。
由于 CDT 的预测价值仅略低，与应用的 MCI 概念相比，其快速应用和评分，因此值得改进 CDT 评分系统，以提高痴呆症的预测效力。
