Department of Pediatrics, University of Washington School of Medicine, Seattle, WA, USA.
J Cardiovasc Pharmacol. 2011 Aug;58(2):111-20. doi: 10.1097/FJC.0b013e31820d1b89.
Traditionally, antihypertensive medications were used in few children or adolescents, usually just those with underlying renal or other organ system disease. However, with recent data suggesting that the incidence of primary hypertension may be increasing in the young, it is possible that more children and adolescents will be prescribed antihypertensive agents. This article will review currently available pediatric data on the use of calcium channel blockers, agents affecting the renin-angiotensin-aldosterone system and other classes of antihypertensive medications in children, highlighting appropriate indications and safety considerations. Guidelines for use of antihypertensive medications, including choice of initial agent and how to prescribe appropriately, will be presented.
传统上,降压药物在儿童或青少年中使用较少,通常仅用于患有潜在肾脏或其他器官系统疾病的患者。然而,最近的数据表明,原发性高血压的发病率在年轻人中可能正在增加,因此可能会有更多的儿童和青少年被开处降压药物。本文将综述目前在儿科中应用钙通道阻滞剂、影响肾素-血管紧张素-醛固酮系统和其他类降压药物的数据,重点介绍适当的适应证和安全性考虑。将提出降压药物的使用指南,包括初始药物的选择和如何适当开具处方。