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Cancer: do aspirin and other NSAIDs protect against colorectal cancer?

作者信息

Kraus Sarah, Arber Nadir

出版信息

Nat Rev Gastroenterol Hepatol. 2011 Mar;8(3):125-6. doi: 10.1038/nrgastro.2010.217. Epub 2011 Jan 18.

DOI:10.1038/nrgastro.2010.217
PMID:21243014
Abstract
摘要

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Cancer: do aspirin and other NSAIDs protect against colorectal cancer?癌症：阿司匹林及其他非甾体抗炎药能预防结直肠癌吗？
Nat Rev Gastroenterol Hepatol. 2011 Mar;8(3):125-6. doi: 10.1038/nrgastro.2010.217. Epub 2011 Jan 18.
2
Aspirin for persons at higher risk for colorectal neoplasia.阿司匹林用于患结直肠肿瘤风险较高的人群。
J Fam Pract. 2004 Aug;53(8):637-8; author reply 638.
3
Reduced incidence of colorectal adenoma among long-term users of nonsteroidal antiinflammatory drugs: a pooled analysis of published studies and a new population-based study.非甾体抗炎药长期使用者结直肠腺瘤发病率降低：已发表研究的汇总分析及一项新的基于人群的研究
Epidemiology. 2000 Jul;11(4):376-81. doi: 10.1097/00001648-200007000-00003.
4
Low dose aspirin, COX-inhibition and chemoprevention of colorectal cancer.低剂量阿司匹林、环氧化酶抑制与结直肠癌的化学预防
Curr Top Med Chem. 2005;5(5):493-503. doi: 10.2174/1568026054201631.
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Effect of aspirin and NSAIDs on colorectal adenomas. Protective effect may be spurious.阿司匹林和非甾体抗炎药对结肠直肠腺瘤的影响。保护作用可能是虚假的。
BMJ. 1993 Sep 18;307(6906):734. doi: 10.1136/bmj.307.6906.734-a.
6
Routine aspirin or nonsteroidal anti-inflammatory drugs for the primary prevention of colorectal cancer: recommendation statement.用于结直肠癌一级预防的常规阿司匹林或非甾体抗炎药：推荐声明。
Am Fam Physician. 2007 Jul 1;76(1):109-13.
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Aspirin, non-steroidal anti-inflammatory drugs and protection from colorectal cancer: a review of the epidemiological evidence.阿司匹林、非甾体抗炎药与结直肠癌预防：流行病学证据综述
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Aspirin use and risk for colorectal adenoma.
Ann Intern Med. 2004 Sep 7;141(5):406; author reply 406. doi: 10.7326/0003-4819-141-5-200409070-00020.
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Summaries for patients. Aspirin or nonsteroidal anti-inflammatory drugs for the prevention of colorectal cancer: U.S. Preventive Services Task Force recommendations.
Ann Intern Med. 2007 Mar 6;146(5):I35. doi: 10.7326/0003-4819-146-5-200703060-00003.
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Folic acid and prevention of colorectal adenomas.叶酸与结直肠腺瘤的预防
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Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial.阿司匹林用于结直肠癌肝转移的二级预防（ASAC 试验）：一项多中心随机安慰剂对照试验的研究方案。
Trials. 2021 Sep 20;22(1):642. doi: 10.1186/s13063-021-05587-w.
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Molecular Mechanisms for cAMP-Mediated Immunoregulation in T cells - Role of Anchored Protein Kinase A Signaling Units.T细胞中cAMP介导的免疫调节的分子机制——锚定蛋白激酶A信号单元的作用
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The involvement of endoplasmic reticulum stress in the suppression of colorectal tumorigenesis by tolfenamic acid.

本文引用的文献

1
Effect of aspirin and NSAIDs on risk and survival from colorectal cancer.阿司匹林和 NSAIDs 对结直肠癌风险和生存的影响。
Gut. 2010 Dec;59(12):1670-9. doi: 10.1136/gut.2009.203000. Epub 2010 Sep 15.
2
Non-steroidal anti-inflammatory drug use and colorectal polyps in the Prostate, Lung, Colorectal, And Ovarian Cancer Screening Trial.非甾体抗炎药的使用与前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中的结直肠息肉。
Am J Gastroenterol. 2010 Dec;105(12):2646-55. doi: 10.1038/ajg.2010.349. Epub 2010 Aug 31.
3
Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement.
内质网应激在托芬那酸抑制结直肠肿瘤发生中的作用。
Cancer Prev Res (Phila). 2013 Dec;6(12):1337-47. doi: 10.1158/1940-6207.CAPR-13-0220. Epub 2013 Oct 8.
4
Protein kinase A antagonist inhibits β-catenin nuclear translocation, c-Myc and COX-2 expression and tumor promotion in Apc(Min/+) mice.蛋白激酶 A 拮抗剂抑制 Apc(Min/+) 小鼠中 β-连环蛋白核易位、c-Myc 和 COX-2 的表达及肿瘤促进作用。
Mol Cancer. 2011 Dec 15;10:149. doi: 10.1186/1476-4598-10-149.
5
Modulation of T cell immune functions by the prostaglandin E(2) - cAMP pathway in chronic inflammatory states.慢性炎症状态下前列腺素 E（2）-cAMP 通路对 T 细胞免疫功能的调节。
Br J Pharmacol. 2012 May;166(2):411-9. doi: 10.1111/j.1476-5381.2011.01800.x.
用于癌症预防的阿司匹林和非甾体抗炎药：一项国际共识声明。
Lancet Oncol. 2009 May;10(5):501-7. doi: 10.1016/S1470-2045(09)70035-X.
4
Aspirin for the chemoprevention of colorectal adenomas: meta-analysis of the randomized trials.阿司匹林用于结直肠腺瘤的化学预防：随机试验的荟萃分析
J Natl Cancer Inst. 2009 Feb 18;101(4):256-66. doi: 10.1093/jnci/djn485. Epub 2009 Feb 10.
5
Chemoprevention of colorectal neoplasia: the potential for personalized medicine.结直肠肿瘤的化学预防：个性化医疗的潜力。
Gastroenterology. 2008 Apr;134(4):1224-37. doi: 10.1053/j.gastro.2008.02.012.
6
Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies.阿司匹林对结直肠癌长期风险的影响：来自随机和观察性研究的一致证据。
Lancet. 2007 May 12;369(9573):1603-13. doi: 10.1016/S0140-6736(07)60747-8.
7
The use of aspirin for primary prevention of colorectal cancer: a systematic review prepared for the U.S. Preventive Services Task Force.阿司匹林用于结直肠癌一级预防：为美国预防服务工作组撰写的系统评价
Ann Intern Med. 2007 Mar 6;146(5):365-75. doi: 10.7326/0003-4819-146-5-200703060-00009.
8
Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial.低剂量阿司匹林用于癌症一级预防：妇女健康研究：一项随机对照试验
JAMA. 2005 Jul 6;294(1):47-55. doi: 10.1001/jama.294.1.47.
9
A randomized trial of aspirin to prevent colorectal adenomas.一项关于阿司匹林预防结直肠腺瘤的随机试验。
N Engl J Med. 2003 Mar 6;348(10):891-9. doi: 10.1056/NEJMoa021735.
10
Low-dose aspirin and incidence of colorectal tumors in a randomized trial.一项随机试验中低剂量阿司匹林与结直肠肿瘤发病率的关系
J Natl Cancer Inst. 1993 Aug 4;85(15):1220-4. doi: 10.1093/jnci/85.15.1220.