动态冲击试验与人类骨关节炎软骨的组织病理学和肉眼宏观评估的相关性。
Correlation of dynamic impact testing, histopathology and visual macroscopic assessment in human osteoarthritic cartilage.
机构信息
II. Orthopaedic Clinic, University Hospital Motol, Charles University in Prague, V Úvalu 84, 15006, Prague 5, Czech Republic.
出版信息
Int Orthop. 2011 Nov;35(11):1733-9. doi: 10.1007/s00264-010-1195-1. Epub 2011 Jan 18.
OBJECTIVE
Improved staging of cartilage degeneration is required, particularly during the early stages. We correlated mechanical properties with histological and macroscopic findings.
METHODS
One hundred and twenty cartilage samples were obtained during total knee arthroplasty. Two adjacent plugs were harvested--one for histological classification and one for macroscopic and biomechanical purposes. Dynamic impact testing was performed; normal stress, dissipated energy (∆E), tangent modulus and stiffness were evaluated.
RESULTS
Samples were classified according to six categories of the ICRS histological scale. Mechanical characteristics revealing significant differences between the groups (p < 0.01) were specific damping and related absolute ∆E. A significant correlation was found between the macroscopic score and specific damping, as well as absolute and relative ∆E (p < 0.01). A strong relation was revealed between relative ∆E and cartilage thickness (p < 0.001; R (2) = 0.69).
CONCLUSIONS
Only ∆E correlated with the condition of the cartilage--the value increased with decreasing quality-and is the most suitable characteristic. This change appears substantial in initial stages of cartilage deterioration.
目的
需要改进软骨退变的分期，特别是在早期阶段。我们将力学性能与组织学和宏观发现相关联。
方法
在全膝关节置换术中获得了 120 个软骨样本。采集了两个相邻的塞子，一个用于组织学分类，一个用于宏观和生物力学目的。进行了动态冲击测试；评估了正常应力、耗散能量（∆E）、切线模量和刚度。
结果
根据 ICRS 组织学量表的六个类别对样本进行分类。在组间表现出显著差异的力学特性（p < 0.01）为特定阻尼和相关的绝对∆E。宏观评分与特定阻尼以及绝对和相对∆E 之间存在显著相关性（p < 0.01）。相对∆E 与软骨厚度之间存在很强的关系（p < 0.001；R (2) = 0.69）。
结论
只有∆E 与软骨的状况相关——随着质量的降低而增加——是最适合的特征。这种变化在软骨退变的早期阶段就显得很明显。
Zotero 插件