[煎煮方法对葛根素在犬体内药代动力学的影响]
[Effect of decoction method on pharmacokinetics of puerarin in dogs].
作者信息
Wang Li, Zhao Ying
机构信息
Heilongjiang University of Chinese Medicine, Harbin 150076, China.
出版信息
Zhong Yao Cai. 2010 Sep;33(9):1442-4.
OBJECTIVE
To investigate the effect of decoction method on pharmacokinetics of Puerarin by determining Puerarin concentration of serum after administration of Gegenqinlian in single (D) and mixed decoction (H) to dogs.
METHODS
HPLC method was established to determine serum concentration of Puerarin and pharmacokinetic parameters were calculated.
RESULTS
The parameters in dogs after administration of H and D were as follows: C(max) was (5.164 +/- 0.637) and (5.383 +/- 0.818) microg/mL, t(max) was (1.10 +/- 0.374) and (1.25 +/- 0.274) h, AUC(0-t) was (25.76 +/- 5.48) and (27.97 +/- 7.16) microg/(h x mL), respectively.
CONCLUSION
Decoction method has significant effect on pharmacokinetic parameters of puerarin in dogs.
目的
通过测定葛根芩连汤单煎（D）与合煎（H）后犬血清中葛根素的浓度，研究煎法对葛根素药代动力学的影响。
方法
建立高效液相色谱法测定血清中葛根素浓度，并计算药代动力学参数。
结果
H组与D组给药后犬的药代动力学参数如下：C(max)分别为(5.164±0.637)和(5.383±0.818)μg/mL，t(max)分别为(1.10±0.374)和(1.25±0.274)h，AUC(0-t)分别为(25.76±5.48)和(27.97±7.16)μg/(h·mL)。
结论
煎法对犬体内葛根素的药代动力学参数有显著影响。
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