葛根素自微乳在比格犬体内的药代动力学及生物利用度
[Pharmacokinetics and bioavailability of Puerarin self-microemulsion in Beagle dogs].
作者信息
Chen Xiao-Xin, Yuan Su, Li Geng, Liang You-Ya, Zhou Xiu, Xie Cheng-Shi, Long Chao-Feng
机构信息
Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China.
出版信息
Zhong Yao Cai. 2011 May;34(5):750-3.
OBJECTIVE
To estabolish a quantitative analysis method for pharmacokinetics and bioavailability of Puerarin self-microemulsion in Beagle dogs.
METHODS
A crossover design was use to detect the pharmacokinetic parameters of Puerarin self-microemulsion and suspension in Beagle dogs. The concentration of Puerarin in plasma was determined with HPLC, the pharmacokinetics parameters and bioavailability was calculated with DAS 2. 1. 1 programs.
RESULTS
T(max) of Puerarin self-microemulsion and suspension were 3.0 h and 2.0 h, C(max) were 2.14 mg/L and 1.061 mg/L, AUC(0-24) were 10.642 mg h/L and 3 mg x h/L, respectively. The bioavailability of Puerarin self-microemulsion relative to Puerarin suspension were 354.73%.
CONCLUSION
Puerarin self-microemulsion can significantly improve the bioavailability in Beagle dogs.
目的
建立比格犬中葛根素自微乳的药代动力学和生物利用度的定量分析方法。
方法
采用交叉设计检测比格犬中葛根素自微乳和混悬液的药代动力学参数。用高效液相色谱法测定血浆中葛根素的浓度，用DAS 2.1.1程序计算药代动力学参数和生物利用度。
结果
葛根素自微乳和混悬液的T(max)分别为3.0小时和2.0小时，C(max)分别为2.14毫克/升和1.061毫克/升，AUC(0 - 24)分别为10.642毫克·小时/升和3毫克·小时/升。葛根素自微乳相对于葛根素混悬液的生物利用度为354.73%。
结论
葛根素自微乳可显著提高比格犬的生物利用度。
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