[维拉帕米对大鼠葛根素药代动力学的影响]
[Effect of verapamil on pharmacokinetics of puerarin in rats].
作者信息
Cui Sheng-miao, Ma Yan-bin
机构信息
Department of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2008 Aug;33(16):2033-6.
OBJECTIVE
To investigate the effect of verapamil on the pharmacokinetics of puerarin in rats.
METHOD
Puerarin with or without verapamil was administered intravenously or orally to rats. The concentration of puerarin in serum was determined by HPLC.
RESULT
No significant difference was found between the control and 0.5 microg x g(-1) verapamil combined groups for intravenous administration, and there was significant difference between the control and 2. 5 microg x g(-1) verapamil combined groups (P < 0.05). When puerarin was administered orally with verapamil, significant difference was found between the control and combined groups (P < 0.05).
CONCLUSION
Verapamil inhibited puerarin metabolism when puerarin was coadministered with verapamil, so it is necessary to change the therapeutic dose of puerarin.
目的
研究维拉帕米对大鼠葛根素药代动力学的影响。
方法
将含或不含维拉帕米的葛根素静脉或口服给予大鼠。采用高效液相色谱法测定血清中葛根素的浓度。
结果
静脉给药时，对照组与0.5μg·g⁻¹维拉帕米联合组之间无显著差异，而对照组与2.5μg·g⁻¹维拉帕米联合组之间存在显著差异（P<0.05）。当葛根素与维拉帕米口服合用时，对照组与联合组之间存在显著差异（P<0.05）。
结论
葛根素与维拉帕米合用时，维拉帕米抑制葛根素代谢，因此有必要改变葛根素的治疗剂量。
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