Wenzhou Medical College, Zhejiang, China.
J Refract Surg. 2011 Jul;27(7):530-41. doi: 10.3928/1081597X-20110112-02. Epub 2011 Jan 17.
To evaluate the current clinical evidence of safety and efficacy of intraoperative topical application of 0.02% mitomycin C (MMC) used for up to 2 minutes after surface ablation for correction of myopia.
A comprehensive literature search was conducted of Cochrane Library, MEDLINE, and EMBASE to identify relevant trials comparing surface ablation for correction of myopia with and without MMC. A meta-analysis was performed on the results of the reports and statistical analysis was performed.
Eleven clinical trials were identified with MMC used in 534 eyes and no MMC in 726 eyes. Surface ablations with MMC led to significantly less corneal haze in photorefractive keratectomy, whereas the results were comparable in laser epithelial keratomileusis (LASEK) and epithelial laser in situ keratomileusis (epi-LASIK). Although proportionately more eyes in the MMC group achieved uncorrected distance visual acuity 20/25 or better and less frequently lost ≥ 2 lines of corrected distance visual acuity, the difference was not statistically significant.
Our meta-analysis suggests that the topical intraoperative application of 0.02% MMC may reduce haze and improve visual acuity after surface ablation for correction of myopia. However, the advantage of using MMC in LASEK and epi-LASIK is unclear.
评估表面消融术后 2 分钟内局部应用 0.02%丝裂霉素 C（MMC）治疗近视的安全性和有效性的当前临床证据。
对 Cochrane 图书馆、MEDLINE 和 EMBASE 进行全面文献检索，以确定比较表面消融术治疗近视并应用和不应用 MMC 的相关试验。对报告结果进行荟萃分析并进行统计分析。
确定了 11 项临床试验，其中 MMC 组有 534 只眼，无 MMC 组有 726 只眼。MMC 组行光折射性角膜切削术时角膜混浊明显减轻，而激光上皮下角膜磨镶术（LASEK）和角膜上皮下激光原位角膜磨镶术（epi-LASIK）的结果相似。尽管 MMC 组更多的眼达到未经矫正的距离视力 20/25 或更好，且较少的眼失去 ≥2 行矫正距离视力，但差异无统计学意义。
我们的荟萃分析表明，表面消融术后局部应用 0.02%MMC 可能减少混浊并改善近视的表面消融术后视力。然而，在 LASEK 和 epi-LASIK 中使用 MMC 的优势尚不清楚。
