氟代芳烃的温和过渡金属无催化氟化胺化反应。
Mild transition-metal-free amination of fluoroarenes catalyzed by fluoride ions.
机构信息
Technische Universität Kaiserslautern, Fachbereich Chemie, Erwin-Schrödinger-Strasse, Geb. 54, 67663 Kaiserslautern, Germany.
出版信息
J Org Chem. 2011 Feb 18;76(4):1151-4. doi: 10.1021/jo102063s. Epub 2011 Jan 18.
PMID:21244085
Abstract
Trimethylsilyl-protected heterocycles undergo N-C bond formation with a variety of electron-deficient fluoroarenes catalyzed by fluoride ions. This reaction avoids stoichiometric amounts of base and thus makes N-arylheterocycles accessible in a very mild and transition-metal-free way.
摘要
三甲基硅基保护的杂环与各种缺电子的氟代芳烃在氟离子催化下发生 N-C 键形成反应。该反应避免了化学计量的碱，因此可以非常温和且无需过渡金属的方式获得 N-芳基杂环。
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