Nikolidakis Dimitris, Jansen John A
Department of Periodontology and Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Tissue Eng Part B Rev. 2008 Sep;14(3):249-58. doi: 10.1089/ten.teb.2008.0062.
Platelet-rich plasma (PRP) is a new approach in tissue regeneration and a developing area for clinicians and researchers. It is used in various surgical fields, including oral and maxillofacial surgery. PRP is prepared from the patient's own blood and contains growth factors that influence wound healing. Of these growth factors, platelet-derived growth factor, transforming growth factor, insulin-like growth factor, and epidermal growth factor play a pivotal role in tissue repair mechanisms. Although the growth factors and mechanisms involved are still poorly understood, the easy application of PRP in the clinic and its possible beneficial outcome, including reduction of bleeding, rapid soft tissue healing, and bone regeneration, hold promise for new treatment approaches. However, animal studies and human trials demonstrate conflicting results regarding the application of PRP. Therefore the aim of this literature review is to evaluate the scientific evidence regarding the use of PRP in dentistry, to describe the different bioactive substances included in PRP and their participation in the healing process, to elucidate the different techniques and available technology for PRP preparation, to review animal and human studies, to clarify risks, and to provide guidance for future research.
富血小板血浆（PRP）是组织再生领域的一种新方法，也是临床医生和研究人员正在开拓的一个领域。它被应用于包括口腔颌面外科在内的各种外科领域。PRP由患者自身血液制备而成，含有影响伤口愈合的生长因子。在这些生长因子中，血小板衍生生长因子、转化生长因子、胰岛素样生长因子和表皮生长因子在组织修复机制中起关键作用。尽管所涉及的生长因子和机制仍未完全清楚，但PRP在临床上易于应用及其可能带来的有益效果，包括减少出血、促进软组织快速愈合和骨再生，为新的治疗方法带来了希望。然而，动物研究和人体试验在PRP的应用方面显示出相互矛盾的结果。因此，这篇文献综述的目的是评估关于PRP在牙科应用的科学证据，描述PRP中包含的不同生物活性物质及其在愈合过程中的作用，阐明PRP制备的不同技术和可用技术，回顾动物和人体研究，明确风险，并为未来研究提供指导。
