Planello Aline C, Campos Maria I G, Meloto Carolina B, Secolin Rodrigo, Rizatti-Barbosa Célia M, Line Sergio R P, de Souza Ana P
Department of Morphology, School of Dentistry, University of Campinas (UNICAMP), Piracicaba, SP, Brazil.
Eur J Oral Sci. 2011 Feb;119(1):1-6. doi: 10.1111/j.1600-0722.2010.00803.x.
Temporomandibular joint (TMJ) degeneration is a frequent cause of orofacial pain. Matrix metalloproteinases (MMPs) degrade extracellular matrix components and play an important role in TMJ degeneration. We investigated the frequency of the MMP1 1G/2G polymorphism (rs1799750), the MMP3 5A/6A polymorphism (rs3025058), and the MMP9 C/T polymorphism (rs3918242) in individuals with TMJ degeneration, in order to analyze the association of polymorphisms in these genes with TMJ degeneration. The population studied comprised 117 healthy controls and 115 individuals diagnosed with TMJ degeneration upon examination of magnetic resonance imaging (MRI) and computed tomography (CT) images. Genotypes were determined using PCR restriction fragment length polymorphism (RFLP). Logistic regression analyses revealed an association between the MMP1 2G/2G genotype and degeneration; in contrast, there was no association between either the MMP3 or the MMP9 genotype and degeneration. Our results may indicate a role for the MMP1 polymorphism in TMJ degeneration.
颞下颌关节（TMJ）退变是口面部疼痛的常见原因。基质金属蛋白酶（MMPs）可降解细胞外基质成分，并在TMJ退变中起重要作用。我们调查了TMJ退变患者中MMP1 1G/2G多态性（rs1799750）、MMP3 5A/6A多态性（rs3025058）和MMP9 C/T多态性（rs3918242）的频率，以分析这些基因多态性与TMJ退变的相关性。研究人群包括117名健康对照者和115名经磁共振成像（MRI）和计算机断层扫描（CT）图像检查诊断为TMJ退变的个体。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）法确定基因型。逻辑回归分析显示MMP1 2G/2G基因型与退变之间存在关联；相比之下，MMP3或MMP9基因型与退变之间均无关联。我们的结果可能表明MMP1多态性在TMJ退变中起作用。
