Departments of Medicine and Biomedical Research, St. Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA 02193, USA.
Trends Cardiovasc Med. 1994 Sep-Oct;4(5):213-21. doi: 10.1016/1050-1738(94)90037-X.
Directional atherectomy has provided the opportunity to study the pathology of restenosis in human tissue specimens from live patients. The restenosis lesion is characterized by two distinctive features: a focus of hypercellularity, comprised of cells with phenotypic features of proliferative vascular smooth muscle cells (SMCs), and a rich, loose extracellular matrix (ECM). Analysis of restenosis lesions by in situ hybridization, immunohistochemistry, and cell culture has disclosed evidence of activated SMCs, and in many cases-particularly lesions from the peripheral vasculature-ongoing cellular proliferation. The ECM of restenosis lesions is biglycan rich and decorin poor, a finding that is associated with increased expression of transforming growth factor beta (TGF-β). While certain restenosis lesions contain foci of microangiogenesis, the pathogenetic significance of this feature remains uncertain.
定向动脉切除术为研究来自活体患者的人组织标本中的再狭窄病理学提供了机会。再狭窄病变的特征是两个显著特征：一个是细胞过度增生的焦点，由具有增殖性血管平滑肌细胞 (SMC) 表型特征的细胞组成，以及丰富、疏松的细胞外基质 (ECM)。通过原位杂交、免疫组织化学和细胞培养对再狭窄病变进行分析，揭示了激活的 SMC 的证据，并且在许多情况下-特别是来自周围血管的病变-持续的细胞增殖。再狭窄病变的 ECM 富含 biglycan 而缺乏 decorin，这一发现与转化生长因子β (TGF-β) 的表达增加有关。虽然某些再狭窄病变包含微血管生成的焦点，但这一特征的发病机制意义仍不确定。
