Institute of Sports Medicine, Department of Orthopaedic Surgery, Bispebjerg Hospital and Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark.
Rheumatol Int. 2012 Apr;32(4):1009-14. doi: 10.1007/s00296-010-1716-7. Epub 2011 Jan 19.
The non-pharmacological treatment of osteoarthritis (OA) includes exercise therapy; however, little is known about the specific effect of exercise on the joint per se. The purpose of the present study was to investigate the direct effects of a load-bearing exercise upon cartilage in a single, human osteoarthritic joint determined by biochemical markers of cartilage turnover and inflammation in the synovial fluid (SF), serum and urine. Eleven subjects with OA of the knee(s), but with no other joint- or inflammatory disorders, volunteered for the study and had samples of blood, urine and synovial fluid drawn both at baseline and following 30-min one-legged knee-extension exercise. Workload: 60% of 1 RM (Repetition Maximum). Determination of cartilage oligomeric matrix protein (COMP), aggrecan, C-terminal collagen II peptide (CTX-II) and interleukin (IL)-6 were performed in synovial fluid (SF), serum and urine. A significant decrease was found in SF concentration of COMP following exercise, whereas aggrecan, CTX-II and IL-6 remained unchanged. No differences in any of the tested markers were found in serum and urine between baseline and post-exercise. Thirty minutes of mechanical loading of a single knee joint in human subjects with knee OA resulted in a reduced COMP concentration in SF.
骨关节炎（OA）的非药物治疗包括运动疗法；然而，对于运动对关节本身的具体影响知之甚少。本研究的目的是通过滑液（SF）、血清和尿液中软骨代谢和炎症的生化标志物来研究负荷运动对单个人类 OA 关节软骨的直接影响。11 名膝关节 OA 但无其他关节或炎症性疾病的受试者自愿参加了这项研究，在基线和 30 分钟单腿膝关节伸展运动后采集了血液、尿液和滑液样本。负荷量：1RM（最大重复次数）的 60%。在滑液（SF）、血清和尿液中测定软骨寡聚基质蛋白（COMP）、聚集蛋白聚糖、C 端胶原 II 肽（CTX-II）和白细胞介素（IL）-6。运动后 SF 中 COMP 的浓度显著下降，而聚集蛋白聚糖、CTX-II 和 IL-6 保持不变。在基线和运动后，血清和尿液中任何测试标志物均无差异。在膝关节 OA 受试者的单个膝关节进行 30 分钟的机械负荷后，SF 中的 COMP 浓度降低。
