National Institute of Oceanography, Regional Centre, Council of Scientific and Industrial Research, Kochi 682 018, India.
Nat Prod Res. 2011 Jan;25(2):169-74. doi: 10.1080/14786419.2010.495069.
Three aromatic sesquiterpene derivatives, (+)-(7R, 10S)-2-methoxy calamenene (1), (+)-(7R, 10S)-2,5-dimethoxy calamenene (2) and (+)-(7R, 10S)-2-methoxy-5-acetoxy calamenene (3) were isolated from the methanol extract of the Indian gorgonian Subergorgia reticulata. Compound 2 has not been previously described in the literature. Compound 3 has not been isolated previously from a natural source. Compounds 1, 2 and 3 showed settlement inhibition activity against cyprids of Balanus amphitrite with EC(50) values of 4.4, 7.8 and 0.03 µg mL(-1), respectively. These compounds also exhibited considerable activity against Artemia nauplii at 50 µg mL(-1), indicative of their potential use as cytotoxic agents.
从印度柳珊瑚 Subergorgia reticulata 的甲醇提取物中分离得到三种芳香倍半萜衍生物：（+）-（7R，10S）-2-甲氧基菖蒲烯（1）、（+）-（7R，10S）-2,5-二甲氧基菖蒲烯（2）和（+）-（7R，10S）-2-甲氧基-5-乙氧基菖蒲烯（3）。化合物 2 在文献中尚未有过描述。化合物 3 以前从未从天然来源中分离得到。化合物 1、2 和 3 对藤壶幼体表现出抑制附着活性，EC50 值分别为 4.4、7.8 和 0.03 µg mL(-1)。这些化合物在 50 µg mL(-1)时对卤虫无节幼体也表现出相当的活性，表明它们具有作为细胞毒性剂的潜力。
