Salmoun M, Braekman J C, Ranarivelo Y, Rasamoelisendra R, Ralambomanana D, Dewelle J, Darro F, Kiss R
Service de Chimie Organique (CP 160/06), Faculté des Sciences, Université Libre de Bruxelles, 50 Avenue F.D. Roosevelt, 1050 Bruxelles, Belgique.
Nat Prod Res. 2007 Feb;21(2):111-20. doi: 10.1080/14786410600899084.
Four calamenene sequiterpenes, (+)-(7R,10S)-15-hydroxycalamenene (3), (+)-(7R,10S)-2,15-dihydroxycalamenene (4), (+)-(7R,10S)-2-hydroxy-15-calamenal (5), (+)-(7R,10S)-15-calamenal (6), along with the amorphane sesquiterpene (+)-(1S,6R,7R,10S)-1-hydroxy-3-oxo-amorph-4-ene (16), have been isolated from the Madagascan shrub Tarenna madagascariensis (Rubiaceae) and their structures determined by spectroscopic methods and chemical correlations. Furthermore, five known related sesquiterpenes [(+)-(7R,10S)-2-hydroxycalamenene (1), (+)-(7R,10S)-3-hydroxycalamenene (2), (-)-alpha-cadinol (13), cadinenal (14), 6-epicadinenal (15)], and three known lignans [(-)-hinokinin, (-)-dihydrocubebin, (-)-cubebin] were also isolated from the same plant. This is the first report of compounds 3, 4, 5, 6, and 16 from a natural source.
从马达加斯加灌木马达加斯加塔伦纳（茜草科）中分离出了四种卡拉烯倍半萜，即(+)-(7R,10S)-15-羟基卡拉烯（3）、(+)-(7R,10S)-2,15-二羟基卡拉烯（4）、(+)-(7R,10S)-2-羟基-15-卡拉烯醛（5）、(+)-(7R,10S)-15-卡拉烯醛（6），以及无羁萜倍半萜(+)-(1S,6R,7R,10S)-1-羟基-3-氧代-无羁萜-4-烯（16），并通过光谱方法和化学关联确定了它们的结构。此外，还从同一植物中分离出了五种已知的相关倍半萜[(+)-(7R,10S)-2-羟基卡拉烯（1）、(+)-(7R,10S)-3-羟基卡拉烯（2）、(-)-α-杜松醇（13）、杜松烯醛（14）、6-表杜松烯醛（15）]，以及三种已知的木脂素[(-)-日桧素、(-)-二氢古巴毕二酚、(-)-古巴毕二酚]。这是化合物3、4、5、6和16首次从天然来源的报道。
