Department of Pathology and Laboratory Medicine, University of British Columbia, Canada.
Can J Neurol Sci. 2010 Sep;37 Suppl 2:S5-15. doi: 10.1017/s0317167100022381.
Multiple sclerosis (MS) has been classically regarded as an inflammatory demyelinating disease of the central nervous system. In recent years, the classification and pathogenesis of the disease have become controversial, particularly with respect to whether an individual patient demonstrates a single or multiple pathogenetic mechanisms in the establishment of the focal plaque of MS. It is also becoming increasingly apparent that there is a significant neurodegenerative component in the disease, involving not only plaques but the non-plaque parenchyma as well. Magnetic resonance imaging, together with histopathologic studies, will continue to shed light on the pathogenesis of these focal and diffuse abnormalities in MS.
多发性硬化症（MS）一直被经典地视为中枢神经系统的炎症性脱髓鞘疾病。近年来，该疾病的分类和发病机制引起了争议，特别是在个体患者是否在 MS 局灶性斑块的建立中表现出单一或多种发病机制方面。越来越明显的是，该疾病存在显著的神经退行性成分，不仅涉及斑块，还涉及非斑块实质。磁共振成像与组织病理学研究将继续阐明 MS 中这些局灶性和弥漫性异常的发病机制。
