Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta.
Can J Neurol Sci. 2010 Sep;37 Suppl 2:S34-41. doi: 10.1017/s0317167100022411.
Stem cell based therapies hold great promise for repair and functional restoration following neurological injury and disease. Skin-derived precursors (or "SKPs") are a novel, multipotent somatic stem cell that resides within the mammalian dermis. SKPs persist within the skin throughout adulthood and yet intriguingly, exhibit many similarities to embryonic neural crest stem cells (NCSCs). For example, SKPs give rise to both neural and mesodermal cell types, and the former appear biased to peripheral nervous system fates. As such, SKPs are capable of generating Schwann cells, the myelinating glial cell of the peripheral nervous system. Here we discuss our current understanding of the biological origin of SKPs and specifically the potential therapeutic utility of SKPs as a highly accessible and autologous source of Schwann cells for remyelination and repair of the injured or diseased nervous system.
基于干细胞的疗法为神经损伤和疾病后的修复和功能恢复带来了巨大的希望。皮肤衍生前体细胞（或“SKP”）是一种新型的、多能的体干细胞，存在于哺乳动物的真皮中。SKP 在整个成年期都存在于皮肤中，但令人好奇的是，它们表现出许多与胚胎神经嵴干细胞（NCSC）相似的特征。例如，SKP 产生神经和中胚层细胞类型，前者似乎偏向于周围神经系统命运。因此，SKP 能够产生雪旺细胞，这是周围神经系统的髓鞘形成胶质细胞。在这里，我们讨论了我们对 SKP 生物学起源的理解，特别是 SKP 作为一种高度可及和自体来源的雪旺细胞，用于髓鞘再生和修复受损或患病神经系统的潜在治疗用途。
