Neuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA.
Sanford Consortium for Regenerative Medicine, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.
Neuromolecular Med. 2021 Sep;23(3):339-343. doi: 10.1007/s12017-021-08663-1. Epub 2021 Apr 24.
Traditionally, the primary role of the meninges is thought to be structural, i.e., to act as a surrounding membrane that contains and cushions the brain with cerebrospinal fluid. During development, the meninges is formed by both mesenchymal and neural crest cells. There is now emerging evidence that subsets of undifferentiated stem cells might persist in the adult meninges. In this mini-review, we survey representative studies of brain-meningeal interactions and discuss the hypothesis that the meninges are not just protective membranes, but instead contain multiplex stem cell subsets that may contribute to central nervous system (CNS) homeostasis. Further investigations into meningeal multipotent cells may reveal a "hidden" target for promoting neurovascular remodeling and repair after CNS injury and disease.
传统上，脑膜的主要作用被认为是结构性的，即作为一种周围的膜，用脑脊液来包含和缓冲大脑。在发育过程中，脑膜是由间充质细胞和神经嵴细胞形成的。现在有新的证据表明，未分化的干细胞亚群可能在成人脑膜中持续存在。在这篇小型综述中，我们调查了大脑脑膜相互作用的代表性研究，并讨论了脑膜不仅是保护膜，而且包含可能有助于中枢神经系统（CNS）稳态的多能干细胞亚群的假说。进一步研究脑膜多能细胞可能揭示出一个“隐藏”的靶点，以促进中枢神经系统损伤和疾病后的神经血管重塑和修复。
