Sakhaee E, Derakhshanfar A
Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Kerman, Iran.
J S Afr Vet Assoc. 2010 Jun;81(2):116-7. doi: 10.4102/jsava.v81i2.117.
This report describes clinical and pathological findings associated with closantel (a halogenated salicylanilide anthelmintic) overdosage in a 3-year-old goat. The clinical signs included blindness, incoordination, ataxia, depression of the palpebral and pupillary reflexes, and recumbency. No gross lesions were noted in tissue or organs at necropsy, but microscopic lesions were seen in nervous tissue and hepatic cells. Polioencephalomalacia was clearly evident. Bilaterally symmetrical status spongiosus of the white matter of the brain, bilateral laminar necrosis, microcavitations, ischaemic cell change and severe degeneration of the cerebellum were seen in nervous tissue. Fatty change and hydropic degeneration in the liver and hepato-cellular degeneration were observed histologically.
本报告描述了一只3岁山羊过量服用氯氰碘柳胺（一种卤化水杨酰苯胺驱虫药）后的临床和病理表现。临床症状包括失明、共济失调、运动失调、眼睑和瞳孔反射抑制以及卧地不起。尸检时在组织或器官中未发现肉眼可见的病变，但在神经组织和肝细胞中发现了微观病变。脑软化明显可见。神经组织中可见双侧对称性脑白质海绵样变、双侧层状坏死、微腔形成、缺血性细胞改变以及小脑严重变性。组织学观察发现肝脏出现脂肪变性和水样变性以及肝细胞变性。
