Ophthalmology, Galway University Hospitals, Galway, Ireland
Ophthalmology, Galway University Hospitals, Galway, Ireland.
BMJ Case Rep. 2023 Feb 9;16(2):e249626. doi: 10.1136/bcr-2022-249626.
Closantel is a broad-spectrum antihelminthic agent. It is a veterinary drug used only in animals-usually cattle, sheep and goats. A man in his 60s accidentally ingested approximately 1500 mg closantel. His visual acuity deteriorated. Optical coherence tomography (OCT) showed disruption of the outer retinal layers. Electroretinography identified abnormalities in macula and inner retinal function. He received methylprednisolone 1 g daily intravenously for 3 days. Improvements in both his visual acuity and OCT appearance followed. This case illustrates the profoundly destructive effect of this drug on humans even when consumed in low dose. We provide a concise summary of the small number of cases of closantel toxicity in humans, previously reported, for future reference as needed by others.
氯硝柳胺是一种广谱抗蠕虫药物。它是一种兽医专用药物，仅用于动物——通常是牛、羊和山羊。一名 60 多岁的男子不慎摄入了大约 1500 毫克的氯硝柳胺。他的视力下降。光学相干断层扫描（OCT）显示外视网膜层中断。视网膜电图显示黄斑和视网膜内层功能异常。他每天接受 1 克甲基强的松龙静脉注射，共 3 天。视力和 OCT 外观均有所改善。本例说明即使摄入低剂量，这种药物对人体也有严重的破坏性影响。我们简要总结了之前报道的少数几例氯硝柳胺毒性病例，以备将来有需要时参考。
