Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Org Lett. 2011 Feb 18;13(4):628-31. doi: 10.1021/ol102867x. Epub 2011 Jan 19.
Two novel alkaloids with a furo[2,3-b]pyrazin-2(1H)-one moiety and a guanidino group, hyrtioseragamines A (1) and B (2), have been isolated from an Okinawan marine sponge Hyrtios species. The structures of 1 and 2 were elucidated on the basis of spectroscopic data and chemical conversions. Compounds 1 and 2 are the first natural products possessing a furo[2,3-b]pyrazine-related moiety.
两种新型生物碱，具有呋喃[2,3-b]吡嗪-2(1H)-酮部分和胍基，hyrtioseragamines A（1）和 B（2），已从冲绳海洋海绵 Hyrtios 物种中分离出来。根据光谱数据和化学转化，确定了 1 和 2 的结构。化合物 1 和 2 是第一个具有呋喃[2,3-b]吡嗪相关部分的天然产物。
