Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Org Lett. 2013 Apr 19;15(8):2010-3. doi: 10.1021/ol400687b. Epub 2013 Apr 9.
Three new alkaloids, hyrtimomines A-C (1-3), were isolated from an Okinawan marine sponge Hyrtios sp. The structures of 1-3 were elucidated on the basis of spectroscopic analysis and application of a phenylglycine methyl ester (PGME) method. Hyrtimomines A (1) and B (2) are heteroaromatic alkaloids possessing a fused hexacyclic 6/5/6/6/7/5 ring system, while hyrtimomine C (3) is an alkaloid consisting of hydroxyindole and azepino-hydroxyindole moieties. Hyrtimomine A (1) exhibited cytotoxicity against KB and L1210 cells.
从冲绳海洋海绵 Hyrtios 中分离得到三种新的生物碱，hyrtimomines A-C（1-3）。基于光谱分析和苯甘氨酸甲酯（PGME）方法的应用，确定了 1-3 的结构。Hyrtimomines A（1）和 B（2）是具有稠合六环 6/5/6/6/7/5 环系的杂芳族生物碱，而 hyrtimomine C（3）是由羟基吲哚和氮杂环庚基-羟基吲哚部分组成的生物碱。Hyrtimomine A（1）对 KB 和 L1210 细胞表现出细胞毒性。
